Coronary microvascular dysfunction as a result of systematic inflammation in psoriasis patients was ameliorated manifested as an increase in the coronary flow reserve (CFR) from 2.2 ± 0.7 to 3.02 ± 0.8 (p < 0.0001) after anti-TNF-α therapy (Piaserico et al., 2016). The gene discussed is TNF; the disease is psoriasis.