Adipokines, a group of proteins secreted by adipocytes, including leptin, visfatin, and resistin, promote the inflammatory condition in psoriasis patients by the correlation with immune cells and pro-inflammatory factors, which in turn results in the appearance of an abnormal serum adipokine profile in patients with psoriasis (Toussirot et al., 2014). The gene discussed is RETN; the disease is psoriasis.