We discuss the overlapping mechanisms between psoriasis and associated cardiometabolic comorbidities, especially the shared inflammatory pathways between psoriasis and cardiometabolic diseases linked to a sequence of inflammatory cascade reactions driven by increased T helper 1 (Th1), Th17 lymphocytes and associated proinflammatory cytokines, including TNF-α, IL-1β, IL-17 and IL-23 (Davidovici et al., 2010). The gene discussed is TNF; the disease is psoriasis.