The critical T-cell differentiation into Th1 and Th17 cells, which is stimulated by IL-12 and IL-23 and leads to the release of cytokines such as TNF-α, IFN-γ, IL-17, and IL-22 in the process of adaptive immunity, overlaps between psoriasis and cardiometabolic diseases leading to augmented keratinocyte proliferation and angiogenesis (Lockshin et al., 2018). This evidence concerns the gene IL17A and psoriasis.