DUSP6 and gastric neoplasm: Wu et al. (2018) reported that elevated DUSP6 expression is related to unfavorable prognosis in gastric tumors and that inhibiting DUSP6 using BCI markedly induced gastric cancer cell apoptosis and suppressed its proliferation. Additionally, an in vitro study found that BCI attenuates lipopolysaccharide (LPS)-induced proinflammatory responses in macrophages by activating Nrf2 (Zhang et al., 2019).