Another study showed that the mixture of RSM extract and Astragalus Membranaceus extract at a ratio of 1:1 could regulate the expression of TGF-β1 and Cyclin D1 to improve liver fibrosis and the liver functions, especially having a good effect on reducing the cyclin D1 expression (Cao et al., 2020). Here, CCND1 is linked to Hepatic fibrosis.