SGLT2-is may prevent the development of atheroma by adjusting dyslipidemia, restoring normal endothelial function, reducing oxidative stress, decreasing inflammation, and inhibiting monocyte-macrophage-foam cell evolution (Terasaki et al., 2015; Leng et al., 2016; Han et al., 2017; Al-Sharea et al., 2018; Dimitriadis et al., 2019; Ganbaatar et al., 2020; Lee et al., 2020; Liu et al., 2021; Park et al., 2021). Here, SLC5A2 is linked to metabolic syndrome.