A meta-analysis including 17 studies with a total of 51,348 participants with T2DM, pre-diabetes, or high risk of diabetes reported a 32% reduction of HF risk (RR, 0.68; 95%CI, 0.63–0.73) in SGLT2-i users (Zhu et al., 2020). This evidence concerns the gene SLC5A2 and hydrops fetalis.