ACKR3 and acute respiratory distress syndrome: Since the pathological mechanisms of LPS-induced ALI/ARDS can vary between the early and late phases of the inflammatory response (Domscheit et al., 2020), this model was characterized over time for the main features of ALI/ARDS, namely, lung dysfunction, vascular permeability, inflammatory cell recruitment, and CXCR3/CXCR4/CXCR7 chemokine ligands release.