To elucidate the role of CXCR7 on pulmonary inflammation, an ALI/ARDS experimental model was established through inhalation of nebulized lipopolysaccharide (LPS) in DBA/1 mice, a strain susceptible to LPS-induced ALI (Alm et al., 2010) and known to express both CXCL11 and CXCL12 (Richard-Bildstein et al., 2020). This evidence concerns the gene CXCL12 and acute respiratory distress syndrome.