We discovered these genes (MMP9, MPO, S100A9, MMP8, FN1, HP, S100A8, ELANE, CAMP, NGP, and FCNB) encoding proteins mostly about chronic inflammatory response, and these genes might be involved in the anti-inflammatory effect of BoNT/A against arthritis pain (Figure 5E). The gene discussed is FN1; the disease is arthritic joint disease.