Significant reduction in FPG, insulin, insulin resistance (by HOMA−IR) and TG concentrations and an increase in HDL.C was seen over the 12 weeks of study in each group. Adjusting to the baseline measurements, there was significant difference in FPG, HOMA−IR, serum insulin, TG and HDL.C among the groups after 12 weeks of the study. The calcium plus calcitriol group showed a significant decrease in ALT and FPG and increase in HDL.C level compared with the calcitriol group, adjusted to the baseline measures. This evidence concerns the gene INS and Insulin resistance.