Atractylodes lactone II at a dose of 100 mg/L can exert a shear effect on the activities of Poly (ADP-ribose) polymerase 1 (PARP1) and caspase 3, and with an increase in drug concentration, the shear effect is enhanced, Atractylodes lactone II can modulate the activity of PARP1, and caspase 3 protein expression promotes colorectal cancer Lovo cell apoptosis (Zhang et al., 2017). This evidence concerns the gene CASP3 and colorectal cancer.