For instance, considering that opioid use exacerbates the up regulation of IL-6 (Lu et al., 2019), it may worsen the inflammation and consequent cardiovascular outcomes (e.g., myocarditis, plaque rupture) related to the cytokine storm of L-6, IL-7, and IL-22 induced by the viral invasion of SARS-CoV-2. Here, IL22 is linked to myocarditis.