The IHC staining showed higher expression of HER2 in OSCC tissues than normal adjacent tissues (p = 6.89 × 10−6 for early stage and p = 3.26 × 10−5 for middle & advanced stage), and also in cancer tissues from middle & advanced than early stage OSCC (p = 0.038) (Figure 1B), demonstrating that the level of HER2 expression was gradually increased with the progression of OSCC. This evidence concerns the gene ERBB2 and cancer.