High HER2 expression due to gene amplification drives oncogenic signaling in various organs and tissues of cancer origin including esophagogastric, breast, head, and neck and other types of cancer (Cierpikowski et al., 2018; Grenda et al., 2020; Pennacchiotti et al., 2021; Sanz-Moreno et al., 2021). The gene discussed is ERBB2; the disease is cancer.