NLRP3 and neuropathy: Previous studies found that NLRP3 inflammasome activation and downstream DRG inflammation led to painful neuropathy, lumbar disc herniation, and bortezomib-induced mechanical allodynia in type 2 diabetic rodents (Jin et al., 2017; Zhang et al., 2017; Liu et al., 2018; Thakur et al., 2020).