Besides, many convinced results also reported that mutations within autophagy-related genes such as PTEN induced putative kinase 1 (PINK1), PARKIN, PARK7 (DJ-1) play an essential role in mitochondrial dysfunction and the dysfunction of mitochondria can successively induce a series of metabolic disorders (Kasten et al., 2018). The gene discussed is PINK1; the disease is Other metabolic disease.