SETD1A and Cognitive impairment: Setd1a+/– mice express impairments in social behavior as well as in working memory and learning (Mukai et al., 2019; Nagahama et al., 2020) which resemble some of the known deficits in human individuals with SETD1A haploinsufficiency, i.e., reductions in social skills, learning difficulties and cognitive impairments (Owen et al., 2016; Singh et al., 2016; Kummeling et al., 2020).