Knockout of the receptor impairs microglial response in AD, leading to an exacerbated sensibility to stress-induced cell death (Zheng et al., 2017; Liu et al., 2020; McQuade et al., 2020), with reports highlighting the emergence of susceptibility only upon TREM2 haploinsufficiency (Sayed et al., 2018). The gene discussed is TREM2; the disease is Alzheimer disease.