This role in myelin recycling is also key in AD, as mutant microglia for TREM2 overly produce autophagic vesicles via a deficit in the mammalian target for rapamycin (mTOR) pathway, leading to AD pathologies in the 5XFAD mouse model (Ulland et al., 2017). The gene discussed is TREM2; the disease is Alzheimer disease.