The implication of purinergic receptors in aging is still elusive, but cognitive decline-related disease conditions involving inflammation, such as Alzheimer’s disease (AD), show a consistent up-regulation of P2X7 in microglia (Woods et al., 2016; Francistiová et al., 2020; Pietrowski et al., 2021). Here, P2RX4 is linked to Alzheimer disease.