We have shown that in KM rats, compared with W and “0” rats, there was a decrease in the transcription of the Igfbp5 and Gstm1 genes, the mutations of which were shown to increase the risk of developing epilepsy in humans (Reddy, 2004; Jamali et al., 2006; Ercegovac et al., 2015; Prabha et al., 2016). The gene discussed is IGFBP5; the disease is epilepsy.