MAPK3 and status epilepticus: On the other hand, it was previously demonstrated that activation of glutamate via NMDA and AMPA and kainate receptors during seizures leads to an increase in ERK1/2 activity, which causes suppression of the functional activity and sensitivity of GABAA receptors in the granular cells of the dentate gyrus in the hippocampus, making the entire hippocampus susceptible to seizures and status epilepticus development (Kapur, 2018).