DCHS1 and Cognitive impairment: Interestingly, this enrichment of 5hmC marks occurred within or at least in close proximity to neurogenic genes, such as Emx1, Prox1, Eomes, Dll3, Tcf4, Tubb3, Wnt family members, and Dchs1. The cell-adhesion protein DCHS1, for example, is described to play a pivotal role in human and murine corticogenesis, leading to cortical malformations, heterotopia of neuronal populations, and cognitive impairments when being dysregulated in expression, which is described for syndromes such as Van Maldergem’s (Supplementary Table S1; Cappello et al., 2013).