Another example of SETDB1 as potential critical factor for NDDs is discussed for major depressive disorder (MDD), which affects a high number of world wide’s population, displays a prominent comorbidity with diverse neuropsychiatric diseases (Table 2 and Supplementary Table S1), and results from dysregulated milestones during brain development (Melartin et al., 2002; Depping et al., 2018; Lima-Ojeda et al., 2018; Schmitgen et al., 2019; Zhu et al., 2020). Here, SETDB1 is linked to major depressive disorder.