In the mouse model, a prenatal Dnmt1-deficiency in Nestin-expressing neural stem cells promoted the differentiation into astrocytes by increasing astrocyte marker glial fibrillary acidic protein (Gfap) and attenuating neurogenesis during corticogenesis, which was correlated with more prominent anxiety-like behavior in adult mice (Supplementary Table S1; Hutnick et al., 2009; Noguchi et al., 2016). The gene discussed is GFAP; the disease is Anxiety.