CREBBP and Cornelia de Lange syndrome: With the exception of a single patient presenting with classic CdLS (Woods et al., 2014), the other individuals with variants in CREBBP and EP300 appear to be associated with a rather non-classic form of CdLS (average clinical score of 9) (Aoi et al., 2019; Tang et al., 2019; Cucco et al., 2020).