Liu et al. (2015) and Hwang et al. (2010) reported changes in synaptophysin levels after 12 weeks and 9–12 months of HFD, respectively. Interestingly, in many neurological disorders, inflammation, neuronal degeneration and synaptic dysfunction coexist (Di Filippo et al., 2008, 2013). This evidence concerns the gene SYP and nervous system disorder.