Gaspar et al. also reported recently that pollen extracts induced an increase in the release of IL6 and IL8 cytokines, as measured by flow cytometry, possibly as a result of the activation of protease-activated receptor 2 (PAR-2), based on the fact that pollens are important triggers for allergic rhinitis, conjunctivitis, and asthma [43]. Here, F2RL1 is linked to asthma.