CD4 and metabolic dysfunction-associated steatohepatitis: In chronic hepatitis B patients, exosomes derived from CD4+ and CD8+ T cells are released into serum, while in patients with nonalcoholic steatohepatitis (NASH) or nonalcoholic liver disease (NAFLD), high level of macrophage/monocyte-derived and invariant natural killer (iNKT) cell-derived exosomes are released into the serum [40].