HULC and hepatocellular carcinoma: Based on the fact that lncRNAs can be used as ceRNAs to regulate miRNAs, experiments have observed that HULC can act as a sponge to inhibit miR-107 to upregulate E21F, thereby promoting the expression of Sphk1. Therefore, these results indicate that HULC sponges miR-107 and activates the SphK1 promoter under the action of the transcription factor E2F1, induces the upregulation of SphK1, and finally stimulates the angiogenesis of HCC 170.