Based on the fact that lncRNAs can be used as ceRNAs to regulate miRNAs, experiments have observed that HULC can act as a sponge to inhibit miR-107 to upregulate E21F, thereby promoting the expression of Sphk1. Therefore, these results indicate that HULC sponges miR-107 and activates the SphK1 promoter under the action of the transcription factor E2F1, induces the upregulation of SphK1, and finally stimulates the angiogenesis of HCC 170. Here, SPHK1 is linked to hepatocellular carcinoma.