PPARA and hepatocellular carcinoma: Given that ACSL1 is activated by the transcription factor PPARA 183, overexpression of ACSL1 further increases the uptake of FAs in HCC cells 184, and its product cholesterol upregulates HULC by activating RXRA. Hence, forming a positive feedback loop to upregulate the level of HULC in hepatoma cells leads to abnormal lipid metabolism and accelerates the occurrence of HCC 132.