HDAC1 and breast carcinoma: We detected a significant decrease in HDAC1 expression in MCF-7, MDA-MB-231, SKBR3 and JIMT-1 breast cancer cells that were treated with NSC/JQ1 combination as compared to control or single treatment (Fig. 6B), thus suggesting a novel role of this combination to by targeting HDAC1 expression to suppress breast cancer cells growth.