They also found that while anti-IL-1β monoclonal antibodies considerably inhibit atherosclerotic vascular calcification in Ldlr-/- mice with hypercholesterolemia, they induce only an insignificant change in the atherosclerotic vascular calcification of Pcsk9(Tg) mice with indiscriminate hypercholesterolemia. This evidence concerns the gene LDLR and familial hypercholesterolemia.