PTPDC1 and cancer: The results of subgroup analysis showed the PTPDC1 expression in tissues of GC patients was significantly correlated with individual cancer race, age, subtypes, and stages (Fig. 4A-D). TCGA data showed that PTPDC1 expression was up regulated in the tumor tissues contrasted with expression in normal tissues (Fig. 4E). To validate the analysis finding, we examined and quantified the expression of circ-PTPDC1 by qRT-PCR in 128 paired clinical GC tissues and matched non-tumor tissues from GC patients, the sub-pathological types of the selected samples was shown in Table S2.