SMAD1 and renal carcinoma: In the present work, miR-196a significantly induces renal cancer cell proliferation, migration and invasion by directly targets 3'UTR of Bram1 both in vitro and in vivo. Further investigation revealed that the underlining mechanism of Bram1 suppression is via the inhibition of Smad1/5/8 phosphorylation and MAPK pathway by directly binding to BMPR1A and EGFR.