Moreover, in PD models of Drosophila expressing Pink and Parkin mutant, supplementing dietary stearic acid (C18:0) can increase TFR1 acylation, and thus rescue the mitochondrial dysfunction and PD phenotypes caused by genetic defects 58, which identifies FA as a key regulator of mitochondrial function via acylation in neurodegeneration. The gene discussed is PRKN; the disease is Parkinson disease.