Considering inflammation and apoptosis plays a significant role during NASH 2, 3, 5, and SOCS2 can also inhibit insulin resistance 12, we think that SOCS2 in macrophages may play a major function, as an suppressor, for NASH progression and it in hepatocytes play a secondary role. This evidence concerns the gene SOCS2 and metabolic dysfunction-associated steatohepatitis.