To explore whether hepatic steatosis caused by GHR KO in pigs also occurs in humans, siGHR was transfected into two human hepatocyte lines, HepG2 and L02, to silence GHR. Western blot analysis showed that GHR expression was markedly decreased in siGHR-treated human hepatocytes (Figure 4A). The gene discussed is GHR; the disease is Hepatic steatosis.