Although three gene expressions change upon cuprizone treatment, solely is not sufficient to claim that oligodendrocyte maturation and survival is changed; it was only hypothesized that oligodendrocyte cell death and further survival/maturation changes in MS pathogenesis may be associated with the Cxcr4, Cntf and Nrg1 gene expressions. This evidence concerns the gene CNTF and myeloid sarcoma.