The most significant pathways identified are dilated cardiomyopathy (DCM), hypertrophic cardiomyopathy (HCM), thalassemia, left ventricular noncompaction (LVNC), arterial septal defect, sickle cell anemia (SCA), alpha-1-antitrypsin (A1AT) deficiency, chronic obstructive pulmonary disease (COPD), etc. Among these, the COPD is related to lung physiology. This evidence concerns the gene SERPINA1 and chronic obstructive pulmonary disease.