In silico studies have reported that some of the active ingredients of propolis, especially some flavonoids, have a higher binding potential than antiviral drugs (hydroxychloroquine and remdesivir) used in COVID-19 spike protein and ACE-2 (Mady et al., 2020; Shaldam et al., 2020; Güler and Kara, 2020; Guler et al., 2021). The gene discussed is ACE2; the disease is COVID-19.