Vitamin C exhibits immunomodulatory activity, increases interferon production through STAT3 phosphorylation, limits organ damage caused by cytokines, supports survival in fatal infections, and most importantly, it can recycle oxidized quercetin (Li et al., 2006; Askari et al., 2012; Kim et al., 2013; Valero et al., 2015). The gene discussed is STAT3; the disease is infection.