Several drugs including peroxisome proliferator-activated receptors (PPARs) agonists, cyclooxygenase (COX) inhibitors, and sphingosine-1-phosphate receptor 1 (S1P1) which have been experimentally shown to be effective in reducing cytokine storm associated with influenza infection, may also be considered to use for severe COVID-19 in the future. Here, S1PR1 is linked to COVID-19.