Several drugs including peroxisome proliferator-activated receptors (PPARs) agonists, cyclooxygenase (COX) inhibitors, and sphingosine-1-phosphate receptor 1 (S1P1) which have been experimentally shown to be effective in reducing cytokine storm associated with influenza infection, may also be considered to use for severe COVID-19 in the future. The gene discussed is S1PR1; the disease is influenza.