BRCA1 and breast carcinoma: Thepresence of hereditary mutations in BRCA1 appears to become one of the most well defined overall risk factors for breast cancer development; moreover, such family mutations, along with family BRCA2 mutations, appear in less than 10% of all cases diagnosed [8].By definition, BRCA1 gene mutations in germ line seem to be practically invisible in sporadic breast cancers [9].