Recently, Albrengues et al. elegantly demonstrated that two NET-associated proteases, neutrophil elastase and matrix metalloproteinase 9 (MMP9), concentrate at laminin, provoke its cleavage, by generating an epitope that induced awakening of dormant cancer cells by integrin activation and FAK/ERK/MLCK/YAP signaling141. Here, MMP9 is linked to cancer.