FMR1 and epilepsy: We conducted enrichment analysis of FMRP protein targets, epilepsy and ID LOF gene lists (Additional file 3: Table S10) across clusters and observed enrichment in the same highly constrained clusters found to be enriched for genes harbouring de novo ASD LOF/missense variants, hereafter referred to as ‘ASD LOF enriched clusters’ (Additional file 4: Table S11).