TP53 and ocular melanoma: Furthermore, advanced studies have shown that miR-612 in OM-MSCs can be transfected into endothelial cells through EVs and promote endothelial cell specification via direct suppression of its target TP53. To the best of our knowledge, this is the first study to show that hypoxic OM-MSC-EVs have the ability to promote angiogenesis and to elucidate the underlying mechanism.