The regulators’ expression details—between LS-SCLC and normal groups—are shown in Fig. 1E. Notably, almost all methyltransferases and binding proteins were upregulated in LS-SCLC; however, the two demethylases tended to exhibit lower expression in LS-SCLC than their normal counterparts. This evidence concerns the gene MBD2 and small cell lung carcinoma.