Minai et al. performed nocturnal oximetry tests on 43 patients with IPAH and CTD-PAH and found that the sleep-disordered breathing group had a higher BNP, higher mRAP, higher mPAP, higher PVR, and lower CI than the no-OSA group, suggesting that sleep-disordered breathing is associated with the progression of PH and the dysregulation of right ventricular function [22]. The gene discussed is NPPB; the disease is sleep apnea syndrome.