Our results formerly demonstrated that compared with lean individuals, KLF15 mRNA expression levels of adipose tissue were markedly decreased in obese individuals, and had a negative correlation with body mass index (BMI), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), while had a positive correlation with high density lipoprotein cholesterol (HDL-C), suggesting downregulated KLF15 expression may relevant to lipid metabolism triggered by obesity [14]. The gene discussed is KLF15; the disease is obesity due to melanocortin 4 receptor deficiency.