To explore the effect of ITGA11 on the evolvement of GC, we constructed an ITGA11 knockdown model in MKN45 and AGS and confirmed the transfection validity by qRT-PCR and WB to figure out the influence of ITGA11 on GC progression (P < 0.05, Figure 2(a-b)). This evidence concerns the gene ITGA11 and gastric cancer.