For the aim of confirming PI3K pathway activation can reversed the anti-tumor role-mediated by si-ITGA11, we added the ITGA11 knockdown plasmid and/or PI3K/AKT agonist IGF-1 into MKN45 to explore the specific mechanism of ITGA11 in GC progression. The gene discussed is PIK3CG; the disease is gastric cancer.