Furthermore, inhibition of sEH has been used to treat rheumatoid arthritis by reducing nociception and inflammation,[67] to reduce inflammation and fibrosis in the host myocardium by inhibiting sEH,[68] and to improve vascular repair in the treatment of Kawasaki disease by inhibiting sEH.[69] sEH inhibitors have recently been shown to be effective in the treatment of sepsis. Here, EPHX2 is linked to rheumatoid arthritis.