EPHX2 and metabolic disease: For example, omega‐3 fatty acid (EPA and DHA)‐derived epoxyeicosanoids show anti‐inflammatory activity in various inflammatory diseases, including in the lung, heart, ocular angiogenesis, and pain.[55] Omega‐3 epoxides (EEQ [epoxyeicosatrienoic acid] and EDP [epoxydocosapentaenoic acid]) stabilized by inhibition of sEH are important regulators of inflammation and autophagy in metabolic diseases.[56] Thus, omega‐3 supplementation may also be synergized with sEH inhibition for suppressing inflammation.[57]