ESR1 and neoplasm: For OS, patients with age > 65, single marital status, Black race, low-median household income (< $50,000), diagnosed from 1998 to 2003, tumor grade III–IV, N3 stage, ER negative, PR negative, HER2 enriched, triple negative breast cancer (TNBC) subtype, radiotherapy and chemotherapy had worse prognosis.