For OS, patients with age > 65, single marital status, Black race, low-median household income (< $50,000), diagnosed from 1998 to 2003, tumor grade III–IV, N3 stage, ER negative, PR negative, HER2 enriched, triple negative breast cancer (TNBC) subtype, radiotherapy and chemotherapy had worse prognosis. The gene discussed is ESR1; the disease is triple-negative breast carcinoma.