If IGH-BCL2, MYD88 L265P, and BRAF V600E were included as supplemental markers of the model, HCL cases could be additionally identified, and the overall sensitivity and specificity could reach 0.88 (173/197) and 0.98 (173/176), respectively (Fig. 3C) (Fig. 5E). The gene discussed is BRAF; the disease is hairy cell leukemia.