Finally, with a set of 35 genes for the classification in total (Table 2) (Supplementary Fig. S2), our model was trained to successively determine whether a sample belongs to CLL/SLL, cMCL, FL, nnMCL, MZL, LPL/WM, or ultimately annotated as “undetermined cases” (Fig. 2C). Here, LPL is linked to B-cell chronic lymphocytic leukemia.