GCGR and type 1 diabetes mellitus: For heterozygous carriers of G40ECDS, which is the most common missense variant in the glucagon receptor (gnomAD MAF: 0.0068), an association with non-insulin-dependent diabetes and central adiposity has been established in men via cohort studies in French/Sardinian patients and a large population study of men (the Olivetti Heart study) (Table 1) (27, 31).