The GRS of the four SNPs studied for association with HOMA-IR (IRS1 rs2943641, IRS1 rs4675095, PPARG rs1801282, and IGF1 rs35767) (Table 4) [10, 11, 33, 34] using equal weights showed an association with HOMA-IR (beta = 1.13, SE = 0.48, p [adjusted for age, BMI, and ethnicity] = 9.72874e−11; p for diabetes [no covariates] = 0.63). This evidence concerns the gene IRS1 and diabetes mellitus.