The immune-related novel metastatic biomarkers in breast cancer were PTCRA, F13A1, LAT, GNG11, ICAM2, NRGN, P2RX1, CLEC1B, BIN2, LPAR5, CCL5, SELP, RUFY1, C6ORF25, TUBB1, GFI1B, C2ORF88, ACRBP, and C17ORF72. Module membership and gene significance of the Immune subnetwork were reported in Additional file 1. Here, ICAM2 is linked to breast cancer.