To prepare cancer cells for migration and intravasation in the early stages of cancer, the keratin family, claudins, and cadherins must be downregulated through the EMT process in primary tumors; still, due to the surviving urgency of CTCs in the bloodstream and avoiding anoikis, a small number of tumor cells must be attached and break off from the primary site [29, 30]. Here, CDH17 is linked to neoplasm.