The EMT-related genes were LRPPRC, AGR2, CLDN4, CRIP1, DSP, ELF3, JUP, KRT8, KRT18, KRT19, FAM102A, TACSTD2, EPCAM, PEBP1, PSMD8, RAN, SNRPC, SPTAN1, EZR, DDR1, MLPH, and WDR34. In which, gene SNRPC, upregulated in CTC clusters, is a metastatic novel biomarker in breast cancer. The gene discussed is SPTAN1; the disease is breast cancer.