The immune-related novel metastatic biomarkers in breast cancer were PTCRA, F13A1, LAT, GNG11, ICAM2, NRGN, P2RX1, CLEC1B, BIN2, LPAR5, CCL5, SELP, RUFY1, C6ORF25, TUBB1, GFI1B, C2ORF88, ACRBP, and C17ORF72. Module membership and gene significance of the Immune subnetwork were reported in Additional file 1. The gene discussed is MPIG6B; the disease is breast carcinoma.