In addition, our present study showed that detecting CSF FGF21 to identify the subjects with high impulsivity tendency will help to find and treat mental disorders with high impulsivity in the early stage, and indicated that modification of CSF FGF21 by exogenous FGF-21 may be used as a new pharmacological therapy for mental disorders characterized by high impulsivity. The gene discussed is FGF21; the disease is psychiatric disorder.