CRP and tuberculosis: In a hypothetical cohort of 1000 outpatients not on ART with 10% tuberculosis prevalence, compared with use of W4SS alone, use of C-reactive protein (≥10 mg/L) would reduce the number of rapid diagnostic tests needed by 272 but miss two additional tuberculosis cases, and use of the sequential strategy of W4SS then C-reactive protein (≥5 mg/L) would reduce the number of rapid diagnostic tests needed by 244 but miss one additional tuberculosis case (figure 3; appendix pp 35–37).