PINK1 and Parkinsonism: This is because the most common onset age for clinic symptoms of patients with PINK1 mutations is between 30 and 40 years (Bentivoglio et al., 2001; Bonifati et al., 2005; Marongiu et al., 2008), though a homozygous missense mutation was found to cause the earliest onset parkinsonism in a 5-year-old boy (Al-Rumayyan et al., 2017).