PINK1 and Parkinson disease: However, these PINK1 KO animal models have not validated the important in vitro findings for the function of PINK1 in mitophagy (Whitworth and Pallanck, 2017; Cummins and Gotz, 2018) or recapitulated selective and overt neurodegeneration seen in PD (Kitada et al., 2007; Gispert et al., 2009; Xiong et al., 2009; Akundi et al., 2011; Zhou et al., 2015; Wang et al., 2016).